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PRELP

GENERAL INFORMATION

Gene name

 PRELP

Gene description

 Proline/arginine-rich end leucine-rich repeat protein

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PRELP (HGNC Symbol)

Synonyms

 prolargin, SLRR2A

Description

 Proline/arginine-rich end leucine-rich repeat protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 203475828 - 203491352

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188783 (version 83.38)

Entrez gene

 5549

UniProt

 P51888 (UniProt - Evidence at protein level)

neXtProt

 NX_P51888

Antibodypedia

 PRELP antibodies

PROTEIN BROWSER
PRELP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRELP-001
ENSP00000343924
ENST00000343110
P51888 [Direct mapping]
Prolargin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007569 [cell aging]
GO:0008201 [heparin binding]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0031012 [extracellular matrix]
GO:0042339 [keratan sulfate metabolic process]
GO:0042340 [keratan sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
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 382 aa
43.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.