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PLA2G2E

GENERAL INFORMATION

Gene name

 PLA2G2E

Gene description

 Phospholipase A2, group IIE

Protein class

 Enzymes
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (tonsil)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA064085
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA064085

GENE INFORMATION

Gene name

 PLA2G2E

Synonyms

Description

 Phospholipase A2, group IIE (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19920009 - 19923617

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188784 (version 83.38)

Entrez gene

 30814

UniProt

 Q9NZK7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZK7

Antibodypedia

 PLA2G2E antibodies

PROTEIN BROWSER
PLA2G2E-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA2G2E-001
ENSP00000364257
ENST00000375116
Q9NZK7 [Direct mapping]
Group IIE secretory phospholipase A2
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
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GO:0004623 [phospholipase A2 activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006954 [inflammatory response]
GO:0016042 [lipid catabolic process]
GO:0036148 [phosphatidylglycerol acyl-chain remodeling]
GO:0036149 [phosphatidylinositol acyl-chain remodeling]
GO:0036150 [phosphatidylserine acyl-chain remodeling]
GO:0036151 [phosphatidylcholine acyl-chain remodeling]
GO:0036152 [phosphatidylethanolamine acyl-chain remodeling]
GO:0044281 [small molecule metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
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 142 aa
16 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.