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GLRA4

GENERAL INFORMATION

Gene name

 GLRA4

Gene description

 Glycine receptor, alpha 4

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Tissue enhanced (smooth muscle)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Cytoplasmic expression in smooth muscle cells in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA044759
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044759

GENE INFORMATION

Gene name

 GLRA4

Synonyms

Description

 Glycine receptor, alpha 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 X

Cytoband

 q22.2

Chromosome location (bp)

 103707224 - 103728655

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000188828 (version 83.38)

Entrez gene

 441509

UniProt

 Q5JXX5 (UniProt - Inferred from homology)

neXtProt

 NX_Q5JXX5

Antibodypedia

 GLRA4 antibodies

PROTEIN BROWSER
GLRA4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRA4-001
ENSP00000361700
ENST00000372617
Q5JXX5 [Direct mapping]
Glycine receptor subunit alpha-4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
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 417 aa
47.7 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.