Expression of ENTPD8 in cancer - Summary - The Human Protein Atlas

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ENTPD8

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ENTPD8
Gene description	Ectonucleoside triphosphate diphosphohydrolase 8
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, RPMI-8226, T-47d)
HPA (normal tissue):	Tissue enhanced (colon, duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membrane expression in intestines and liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA021509
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable).
Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021509

GENE INFORMATION
Gene name	ENTPD8 (HGNC Symbol)
Synonyms	NTPDase-8, UNQ2492
Description	Ectonucleoside triphosphate diphosphohydrolase 8 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137434364 - 137441816
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000188833 (version 83.38)
Entrez gene	377841
UniProt	Q5MY95 (UniProt - Evidence at protein level)
neXtProt	NX_Q5MY95
Antibodypedia	ENTPD8 antibodies

PROTEIN BROWSER

ENTPD8-001	ENTPD8-003	ENTPD8-004	ENTPD8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENTPD8-001 ENSP00000344089 ENST00000344119	Q5MY95 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 8 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	458 aa 49.4 kDa	Yes	1
ENTPD8-003 ENSP00000420531 ENST00000472938	Q5MY95 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 8 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	495 aa 53.9 kDa	Yes	1
ENTPD8-004 ENSP00000420099 ENST00000493135	H7C5J8 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 8 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	223 aa 23.6 kDa	Yes	0
ENTPD8-201 ENSP00000360561 ENST00000371506	Q5MY95 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 8 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0009124 [nucleoside monophosphate biosynthetic process] GO:0009133 [nucleoside diphosphate biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0017110 [nucleoside-diphosphatase activity] GO:0017111 [nucleoside-triphosphatase activity] GO:0046872 [metal ion binding] Show all	495 aa 53.9 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.