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ASTL

GENERAL INFORMATION

Gene name

 ASTL

Gene description

 Astacin-like metallo-endopeptidase (M12 family)

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA015620
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015620

GENE INFORMATION

Gene name

 ASTL (HGNC Symbol)

Synonyms

 ovastacin, SAS1B

Description

 Astacin-like metallo-endopeptidase (M12 family) (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 96123850 - 96138436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188886 (version 83.38)

Entrez gene

 431705

UniProt

 Q6HA08 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6HA08

Antibodypedia

 ASTL antibodies

PROTEIN BROWSER
ASTL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASTL-001
ENSP00000343674
ENST00000342380
Q6HA08 [Direct mapping]
Astacin-like metalloendopeptidase
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007155 [cell adhesion]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009566 [fertilization]
GO:0010954 [positive regulation of protein processing]
GO:0030133 [transport vesicle]
GO:0060468 [prevention of polyspermy]
GO:0060473 [cortical granule]
GO:0070001 [aspartic-type peptidase activity]
GO:0070002 [glutamic-type peptidase activity]
GO:2000360 [negative regulation of binding of sperm to zona pellucida]
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 431 aa
45.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.