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HUS1B

GENERAL INFORMATION

Gene name

 HUS1B

Gene description

 HUS1 checkpoint clamp component B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed
0.05.0101520253035404550556065FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HUS1B

Synonyms

Description

 HUS1 checkpoint clamp component B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p25.3

Chromosome location (bp)

 655939 - 656963

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000188996 (version 83.38)

Entrez gene

 135458

UniProt

 Q8NHY5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NHY5

Antibodypedia

 HUS1B antibodies

PROTEIN BROWSER
HUS1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HUS1B-001
ENSP00000370293
ENST00000380907
Q8NHY5 [Direct mapping]
Checkpoint protein HUS1B
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Predicted intracellular proteins
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GO:0000077 [DNA damage checkpoint]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0030896 [checkpoint clamp complex]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0033314 [mitotic DNA replication checkpoint]
GO:0035861 [site of double-strand break]
GO:0044778 [meiotic DNA integrity checkpoint]
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 278 aa
31 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.