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FAM111B

GENERAL INFORMATION

Gene name

 FAM111B

Gene description

 Family with sequence similarity 111, member B

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA038637
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA038637

GENE INFORMATION

Gene name

 FAM111B (HGNC Symbol)

Synonyms

 CANP

Description

 Family with sequence similarity 111, member B (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59107185 - 59127410

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189057 (version 83.38)

Entrez gene

 374393

UniProt

 Q6SJ93 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6SJ93

Antibodypedia

 FAM111B antibodies

PROTEIN BROWSER
FAM111B-001
FAM111B-002
FAM111B-004
FAM111B-201
FAM111B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAM111B-001
ENSP00000341565
ENST00000343597
Q6SJ93 [Direct mapping]
Protein FAM111B
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 734 aa
84.7 kDa 		No 0
FAM111B-002
ENSP00000432875
ENST00000529618
Q6SJ93 [Direct mapping]
Protein FAM111B
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 704 aa
81.2 kDa 		No 0
FAM111B-004
ENSP00000432143
ENST00000534403
E9PS27 [Direct mapping]
Protein FAM111B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
18.4 kDa 		No 0
FAM111B-201
ENSP00000393855
ENST00000411426
Q6SJ93 [Direct mapping]
Protein FAM111B
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 704 aa
81.2 kDa 		No 0
FAM111B-202
ENSP00000483456
ENST00000620384
Q6SJ93 [Direct mapping]
Protein FAM111B
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 734 aa
84.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.