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H1F0

GENERAL INFORMATION

Gene name

 H1F0

Gene description

 H1 histone family, member 0

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-2 OS)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA000843
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000843

GENE INFORMATION

Gene name

 H1F0 (HGNC Symbol)

Synonyms

 H10, H1FV

Description

 H1 histone family, member 0 (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

Chromosome

 22

Cytoband

 q13.1

Chromosome location (bp)

 37805093 - 37807436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189060 (version 83.38)

Entrez gene

 3005

UniProt

 P07305 (UniProt - Evidence at protein level)

neXtProt

 NX_P07305

Antibodypedia

 H1F0 antibodies

PROTEIN BROWSER
H1F0-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H1F0-001
ENSP00000344504
ENST00000340857
P07305 [Direct mapping]
Histone H1.0 Histone H1.0, N-terminally processed
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0005794 [Golgi apparatus]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006334 [nucleosome assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0031490 [chromatin DNA binding]
GO:0044822 [poly(A) RNA binding]
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 194 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.