Cell atlas - ARID2 - The Human Protein Atlas

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ARID2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ARID2
Gene description	AT rich interactive domain 2 (ARID, RFX-like)
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA063044
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (supported)

Additional location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063044	RH-30	Nucleoplasm
	HPA063044	RH-30	Plasma membrane
	HPA063044	SH-SY5Y	Nucleoplasm
	HPA063044	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	ARID2 (HGNC Symbol)
Synonyms	BAF200, DKFZp686G052, FLJ30619, KIAA1557
Description	AT rich interactive domain 2 (ARID, RFX-like) (HGNC Symbol)
Entrez gene summary	ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q12
Chromosome location (bp)	45729665 - 45908040
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189079 (version 83.38)
Entrez gene	196528
UniProt	Q68CP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q68CP9
Antibodypedia	ARID2 antibodies

PROTEIN BROWSER

ARID2-001	ARID2-002	ARID2-003	ARID2-006	ARID2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARID2-001 ENSP00000335044 ENST00000334344	Q68CP9 [Direct mapping] AT-rich interactive domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006337 [nucleosome disassembly] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0016568 [chromatin modification] GO:0046872 [metal ion binding] GO:0090544 [BAF-type complex] Show all	1835 aa 197.4 kDa	No	0
ARID2-002 ENSP00000415650 ENST00000422737	F8WCU9 [Direct mapping] AT-rich interactive domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005488 [binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1639 aa 175.1 kDa	No	0
ARID2-003 ENSP00000397307 ENST00000444670	F8W108 [Direct mapping] AT-rich interactive domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1445 aa 153.1 kDa	No	0
ARID2-006 ENSP00000388357 ENST00000457135	F8VWP4 [Direct mapping] AT-rich interactive domain-containing protein 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	401 aa 42.8 kDa	No	0
ARID2-009 ENSP00000481488 ENST00000477947	A0A087WY37 [Direct mapping] AT-rich interactive domain-containing protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		64 aa 6.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.