Expression of GRAPL in cancer - Summary - The Human Protein Atlas

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GRAPL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GRAPL
Gene description	GRB2-related adaptor protein-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (Daudi, HUVEC TERT2, TIME, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, spleen)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051796
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051796

GENE INFORMATION
Gene name	GRAPL
Synonyms
Description	GRB2-related adaptor protein-like (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19127469 - 19159176
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000189152 (version 83.38)
Entrez gene	400581
UniProt	Q8TC17 (UniProt - Inferred from homology)
neXtProt	NX_Q8TC17
Antibodypedia	GRAPL antibodies

PROTEIN BROWSER

GRAPL-001	GRAPL-003	GRAPL-004	GRAPL-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRAPL-001 ENSP00000437409 ENST00000344415	Q8TC17 [Direct mapping] GRB2-related adapter protein-like Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	118 aa 13.4 kDa	No	0
GRAPL-003 ENSP00000465788 ENST00000437957	K7EKU7 [Direct mapping] GRB2-related adapter protein-like Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	70 aa 8.2 kDa	No	0
GRAPL-004 ENSP00000459618 ENST00000574324	I3L2E9 [Direct mapping] GRB2-related adapter protein-like Show all	Predicted intracellular proteins Show all		65 aa 7.2 kDa	No	0
GRAPL-005 ENSP00000466091 ENST00000577213	K7ELI1 [Direct mapping] GRB2-related adapter protein-like Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	100 aa 11.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.