Expression of HN1 in cancer - Summary - The Human Protein Atlas

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HN1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HN1
Gene description	Hematological and neurological expressed 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA059729
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059729

GENE INFORMATION
Gene name	HN1 (HGNC Symbol)
Synonyms	ARM2, HN1A
Description	Hematological and neurological expressed 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75135248 - 75168281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189159 (version 83.38)
Entrez gene	51155
UniProt	Q9UK76 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK76
Antibodypedia	HN1 antibodies

PROTEIN BROWSER

HN1-001	HN1-004	HN1-005	HN1-006	HN1-010	HN1-012	HN1-013	HN1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HN1-001 ENSP00000387059 ENST00000409753	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	154 aa 16 kDa	No	0
HN1-004 ENSP00000348316 ENST00000356033	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	181 aa 19.9 kDa	No	0
HN1-005 ENSP00000464266 ENST00000476258	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	108 aa 11 kDa	No	0
HN1-006 ENSP00000462834 ENST00000482348	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	108 aa 11 kDa	No	0
HN1-010 ENSP00000462478 ENST00000481647	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	108 aa 11 kDa	No	0
HN1-012 ENSP00000462784 ENST00000470924	Q9UK76 [Direct mapping] Hematological and neurological expressed 1 protein Hematological and neurological expressed 1 protein, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	108 aa 11 kDa	No	0
HN1-013 ENSP00000462805 ENST00000581874	J3KT51 [Direct mapping] Hematological and neurological-expressed 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11 kDa	No	0
HN1-014 ENSP00000462493 ENST00000580380	J3KSH8 [Direct mapping] Hematological and neurological-expressed 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 9.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.