Expression of TSPYL1 in cancer - Summary - The Human Protein Atlas

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TSPYL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TSPYL1
Gene description	TSPY-like 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA031970 , HPA031971
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031970	HPA031971

GENE INFORMATION
Gene name	TSPYL1 (HGNC Symbol)
Synonyms	TSPYL
Description	TSPY-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]
Chromosome	6
Cytoband	q22.1
Chromosome location (bp)	116276578 - 116279903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189241 (version 83.38)
Entrez gene	7259
UniProt	Q9H0U9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0U9
Antibodypedia	TSPYL1 antibodies

PROTEIN BROWSER

TSPYL1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSPYL1-001 ENSP00000357597 ENST00000368608	Q9H0U9 [Direct mapping] Testis-specific Y-encoded-like protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006334 [nucleosome assembly] GO:0008150 [biological_process] GO:0019899 [enzyme binding] Show all	437 aa 49.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.