Cell atlas - FHIT - The Human Protein Atlas

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FHIT

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Plasma membrane

Human cell
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FHIT
Gene description	Fragile histidine triad
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA018909
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & nucleoli (fibrillar center).

Main location

Nucleoli fibrillar center (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018909	HEK 293	Nucleoli fibrillar center
	HPA018909	HEK 293	Plasma membrane
	HPA018909	U-2 OS	Nucleoli fibrillar center
	HPA018909	U-2 OS	Plasma membrane
	HPA018909	U-251 MG	Nucleoli fibrillar center
	HPA018909	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	FHIT (HGNC Symbol)
Synonyms	AP3Aase, FRA3B
Description	Fragile histidine triad (HGNC Symbol)
Entrez gene summary	This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	3
Cytoband	p14.2
Chromosome location (bp)	59749310 - 61251459
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189283 (version 83.38)
Entrez gene	2272
UniProt	P49789 (UniProt - Evidence at protein level)
neXtProt	NX_P49789
Antibodypedia	FHIT antibodies

PROTEIN BROWSER

FHIT-001	FHIT-002	FHIT-003	FHIT-007	FHIT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FHIT-001 ENSP00000417557 ENST00000476844	P49789 [Direct mapping] Bis(5'-adenosyl)-triphosphatase A0A024R366 [Target identity:100%; Query identity:100%] Fragile histidine triad gene, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006163 [purine nucleotide metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009117 [nucleotide metabolic process] GO:0016787 [hydrolase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0047710 [bis(5'-adenosyl)-triphosphatase activity] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	147 aa 16.9 kDa	No	0
FHIT-002 ENSP00000417480 ENST00000468189	P49789 [Direct mapping] Bis(5'-adenosyl)-triphosphatase A0A024R366 [Target identity:100%; Query identity:100%] Fragile histidine triad gene, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006163 [purine nucleotide metabolic process] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009117 [nucleotide metabolic process] GO:0016787 [hydrolase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0047710 [bis(5'-adenosyl)-triphosphatase activity] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	147 aa 16.9 kDa	No	0
FHIT-003 ENSP00000418582 ENST00000492590	P49789 [Direct mapping] Bis(5'-adenosyl)-triphosphatase A0A024R366 [Target identity:100%; Query identity:100%] Fragile histidine triad gene, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006163 [purine nucleotide metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0009117 [nucleotide metabolic process] GO:0016787 [hydrolase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0047710 [bis(5'-adenosyl)-triphosphatase activity] GO:0070062 [extracellular exosome] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] Show all	147 aa 16.9 kDa	No	0
FHIT-007 ENSP00000418596 ENST00000488467	E9PBZ0 [Direct mapping] Bis(5'-adenosyl)-triphosphatase Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	79 aa 9 kDa	No	0
FHIT-201 ENSP00000342087 ENST00000341848	A0A0A0MRB0 [Direct mapping] Bis(5'-adenosyl)-triphosphatase Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	58 aa 6.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.