Expression of ALG1L in cancer - Summary - The Human Protein Atlas

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ALG1L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALG1L
Gene description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CACO-2, HaCaT, MCF7, T-47d)
HPA (normal tissue):	Tissue enhanced (epididymis, urinary bladder)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA036108
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and urothelial cancer (favourable).
Glioma p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036108

GENE INFORMATION
Gene name	ALG1L (HGNC Symbol)
Synonyms	ALG1L1
Description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.2
Chromosome location (bp)	125929275 - 125937039
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000189366 (version 83.38)
Entrez gene	200810
UniProt	Q6GMV1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6GMV1
Antibodypedia	ALG1L antibodies

PROTEIN BROWSER

ALG1L-001	ALG1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG1L-001 ENSP00000340009 ENST00000340333	Q6GMV1 [Direct mapping] Putative glycosyltransferase ALG1-like Show all	Predicted intracellular proteins Show all	GO:0000030 [mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0006486 [protein glycosylation] GO:0097502 [mannosylation] Show all	187 aa 21.1 kDa	No	0
ALG1L-201 ENSP00000482705 ENST00000611639	A0A087WZJ8 [Direct mapping] Putative glycosyltransferase ALG1-like Show all	Predicted intracellular proteins Show all	GO:0000030 [mannosyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0006486 [protein glycosylation] GO:0097502 [mannosylation] Show all	207 aa 23.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.