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GSPT2

GENERAL INFORMATION

Gene name

 GSPT2

Gene description

 G1 to S phase transition 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NTERA-2, PC-3)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044769
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044769

GENE INFORMATION

Gene name

 GSPT2 (HGNC Symbol)

Synonyms

 eRF3b, FLJ10441

Description

 G1 to S phase transition 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 51743431 - 51746232

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189369 (version 83.38)

Entrez gene

 23708

UniProt

 Q8IYD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYD1

Antibodypedia

 GSPT2 antibodies

PROTEIN BROWSER
GSPT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GSPT2-001
ENSP00000341247
ENST00000340438
Q8IYD1 [Direct mapping]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0002184 [cytoplasmic translational termination]
GO:0003747 [translation release factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006415 [translational termination]
GO:0007049 [cell cycle]
GO:0010467 [gene expression]
GO:0018444 [translation release factor complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 628 aa
68.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.