Expression of MMP23B in cancer - Summary - The Human Protein Atlas

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MMP23B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MMP23B
Gene description	Matrix metallopeptidase 23B
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Cell line enhanced (NTERA-2, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MMP23B (HGNC Symbol)
Synonyms	MIFR, MIFR-1, MMP22
Description	Matrix metallopeptidase 23B (HGNC Symbol)
Entrez gene summary	This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1632095 - 1701810
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000189409 (version 83.38)
Entrez gene	8510
UniProt	O75900 (UniProt - Evidence at protein level)
neXtProt	NX_O75900
Antibodypedia	MMP23B antibodies

PROTEIN BROWSER

MMP23B-001	MMP23B-002	MMP23B-003	MMP23B-004	MMP23B-005	MMP23B-010	MMP23B-201	MMP23B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MMP23B-001 ENSP00000348308 ENST00000356026	O75900 [Direct mapping] Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0000003 [reproduction] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] Show all	390 aa 43.9 kDa	No	0
MMP23B-002 ENSP00000367945 ENST00000378675	O75086 [Direct mapping] MIFR-2; Matrix metalloproteinase-23 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] Show all	386 aa 41.6 kDa	No	0
MMP23B-003 ENSP00000426293 ENST00000479814	H0YA69 [Direct mapping] Matrix metalloproteinase-23 Show all	Predicted intracellular proteins Show all		265 aa 28.8 kDa	No	0
MMP23B-004 ENSP00000405867 ENST00000435358	H0Y6I4 [Direct mapping] Matrix metalloproteinase-23 Show all	Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	242 aa 26.5 kDa	No	0
MMP23B-005 ENSP00000424976 ENST00000472264	D6REP6 [Direct mapping] Matrix metalloproteinase-23 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	166 aa 17.2 kDa	No	0
MMP23B-010 ENSP00000426857 ENST00000503792	H0YAE5 [Direct mapping] Matrix metalloproteinase-23 Show all	Predicted intracellular proteins Show all		258 aa 27.4 kDa	No	0
MMP23B-201 ENSP00000482367 ENST00000412810	O75900 [Direct mapping] Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0000003 [reproduction] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] Show all	390 aa 43.9 kDa	No	0
MMP23B-202 ENSP00000482664 ENST00000618459	O75086 [Direct mapping] MIFR-2; Matrix metalloproteinase-23 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0031012 [extracellular matrix] Show all	386 aa 41.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.