Expression of SPOCK3 in cancer - Summary - The Human Protein Atlas

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SPOCK3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SPOCK3
Gene description	Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enhanced (PC-3, RH-30, SCLC-21H)
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SPOCK3 (HGNC Symbol)
Synonyms	testican-3
Description	Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	4
Cytoband	q32.3
Chromosome location (bp)	166733384 - 167234796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196104 (version 83.38)
Entrez gene	50859
UniProt	Q9BQ16 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQ16
Antibodypedia	SPOCK3 antibodies

PROTEIN BROWSER

SPOCK3-001	SPOCK3-002	SPOCK3-005	SPOCK3-006	SPOCK3-010	SPOCK3-012	SPOCK3-013	SPOCK3-014	SPOCK3-015	SPOCK3-016	SPOCK3-017	SPOCK3-018	SPOCK3-021	SPOCK3-022	SPOCK3-023	SPOCK3-201	SPOCK3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPOCK3-001 ENSP00000349677 ENST00000357154	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005539 [glycosaminoglycan binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0019800 [peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan] GO:0031012 [extracellular matrix] Show all	436 aa 49.4 kDa	Yes	0
SPOCK3-002 ENSP00000423606 ENST00000502330	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	436 aa 49.4 kDa	Yes	0
SPOCK3-005 ENSP00000426177 ENST00000512648	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	313 aa 35.6 kDa	Yes	0
SPOCK3-006 ENSP00000350153 ENST00000357545	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	433 aa 49.1 kDa	Yes	0
SPOCK3-010 ENSP00000426318 ENST00000512681	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	338 aa 38.3 kDa	Yes	0
SPOCK3-012 ENSP00000425502 ENST00000511269	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	433 aa 49.1 kDa	Yes	0
SPOCK3-013 ENSP00000426716 ENST00000510741	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	393 aa 44.3 kDa	Yes	0
SPOCK3-014 ENSP00000420920 ENST00000506886	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	436 aa 49.4 kDa	Yes	0
SPOCK3-015 ENSP00000423421 ENST00000511531	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	436 aa 49.4 kDa	Yes	0
SPOCK3-016 ENSP00000425570 ENST00000504953	Q9BQ16 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	433 aa 49.1 kDa	Yes	0
SPOCK3-017 ENSP00000441396 ENST00000535728	A0A0A0MTJ2 [Direct mapping] Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (Testican) 3, isoform CRA_b; Testican-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] Show all	344 aa 39.4 kDa	No	0
SPOCK3-018 ENSP00000423176 ENST00000510403	E7ENT7 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007165 [signal transduction] Show all	173 aa 19.7 kDa	Yes	0
SPOCK3-021 ENSP00000423367 ENST00000509854	E7ENM6 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	161 aa 17.8 kDa	Yes	0
SPOCK3-022 ENSP00000424168 ENST00000506697	E7EMP8 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.6 kDa	Yes	0
SPOCK3-023 ENSP00000425407 ENST00000512042	E7EMP8 [Direct mapping] Testican-3 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.6 kDa	Yes	0
SPOCK3-201 ENSP00000411344 ENST00000421836	Q9BQ16 [Direct mapping] Testican-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	385 aa 44.1 kDa	No	0
SPOCK3-202 ENSP00000444789 ENST00000541354	Q9BQ16 [Direct mapping] Testican-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0031012 [extracellular matrix] Show all	316 aa 36.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.