Cell atlas - MYT1 - The Human Protein Atlas

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MYT1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MYT1
Gene description	Myelin transcription factor 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, REH, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA006303
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, REH, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006303	A-431	Nucleoplasm
	HPA006303	SH-SY5Y	Nucleoplasm	Intensity
	HPA006303	SH-SY5Y	Cytosol	Intensity

GENE INFORMATION
Gene name	MYT1 (HGNC Symbol)
Synonyms	MTF1, MYTI, NZF2, PLPB1, ZC2HC4A
Description	Myelin transcription factor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	64151791 - 64242253
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196132 (version 83.38)
Entrez gene	4661
UniProt	Q01538 (UniProt - Evidence at protein level)
neXtProt	NX_Q01538
Antibodypedia	MYT1 antibodies

PROTEIN BROWSER

MYT1-001	MYT1-002	MYT1-201	MYT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYT1-001 ENSP00000327465 ENST00000328439	Q01538 [Direct mapping] Myelin transcription factor 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001678 [cellular glucose homeostasis] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0008270 [zinc ion binding] GO:0009791 [post-embryonic development] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0030154 [cell differentiation] GO:0031018 [endocrine pancreas development] GO:0032350 [regulation of hormone metabolic process] GO:0060539 [diaphragm development] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] Show all	1121 aa 122.3 kDa	No	0
MYT1-002 ENSP00000353269 ENST00000360149	Q6P6D5 [Direct mapping] MYT1 protein; Myelin transcription factor 1 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] Show all	591 aa 64.6 kDa	No	0
MYT1-201 ENSP00000442412 ENST00000536311	Q01538 [Direct mapping] Myelin transcription factor 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0008270 [zinc ion binding] GO:0030154 [cell differentiation] Show all	1148 aa 125.1 kDa	No	0
MYT1-202 ENSP00000480510 ENST00000622439	Q6P6D5 [Direct mapping] MYT1 protein; Myelin transcription factor 1 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] Show all	591 aa 64.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.