Cell atlas - PLEKHG4 - The Human Protein Atlas

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PLEKHG4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PLEKHG4
Gene description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055696
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions.

Main location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055696	CACO-2	Cell Junctions

GENE INFORMATION
Gene name	PLEKHG4 (HGNC Symbol)
Synonyms	ARHGEF44, DKFZP434I216, SCA4
Description	Pleckstrin homology domain containing, family G (with RhoGef domain) member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67277510 - 67289499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196155 (version 83.38)
Entrez gene	25894
UniProt	Q58EX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q58EX7
Antibodypedia	PLEKHG4 antibodies

PROTEIN BROWSER

PLEKHG4-002	PLEKHG4-004	PLEKHG4-005	PLEKHG4-006	PLEKHG4-011	PLEKHG4-012	PLEKHG4-013	PLEKHG4-016	PLEKHG4-017	PLEKHG4-018	PLEKHG4-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHG4-002 ENSP00000353646 ENST00000360461	Q58EX7 [Direct mapping] Puratrophin-1 A0A024R6X4 [Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family G (With RhoGef domain) member 4, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] GO:0090630 [activation of GTPase activity] Show all	1191 aa 130.8 kDa	No	0
PLEKHG4-004 ENSP00000401118 ENST00000427155	Q58EX7 [Direct mapping] Puratrophin-1 A0A024R6X4 [Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family G (With RhoGef domain) member 4, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] Show all	1191 aa 130.8 kDa	No	0
PLEKHG4-005 ENSP00000368649 ENST00000379344	Q58EX7 [Direct mapping] Puratrophin-1 A0A024R6X4 [Target identity:100%; Query identity:100%] Pleckstrin homology domain containing, family G (With RhoGef domain) member 4, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] Show all	1191 aa 130.8 kDa	No	0
PLEKHG4-006 ENSP00000398030 ENST00000450733	Q58EX7 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] Show all	1110 aa 122.9 kDa	No	0
PLEKHG4-011 ENSP00000454348 ENST00000562144	H3BME5 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.4 kDa	No	0
PLEKHG4-012 ENSP00000455423 ENST00000565899	H3BPQ5 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.3 kDa	No	0
PLEKHG4-013 ENSP00000455876 ENST00000565773	H3BQP9 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		108 aa 11.5 kDa	No	0
PLEKHG4-016 ENSP00000464631 ENST00000569875	J3QSC9 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.4 kDa	No	0
PLEKHG4-017 ENSP00000455622 ENST00000562744	H3BQ60 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.2 kDa	No	0
PLEKHG4-018 ENSP00000455740 ENST00000567938	H3BQE6 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.5 kDa	No	0
PLEKHG4-019 ENSP00000456873 ENST00000568621	H3BSU4 [Direct mapping] Puratrophin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.