Cholangiocarcinomas, stomach and pancreatic cancers along with a few lung, urothelial, cervical and colorectal cancers displayed moderate to strong cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
Moderate to strong cytoplasmic immunoreactivity was observed in stomach cancers and cholangiocarcinomas along with a few pancreatic, colorectal, thyroid, urothelial, cervical, lung and ovarian cancers. Remaining cancer tissues were negative.
Cathepsin E (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]