Expression of CTSE in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CTSE
Gene description	Cathepsin E
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (lung cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Group enriched (BEWO, RT4)
HPA (normal tissue):	Group enriched (duodenum, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression most abundant in stomach but also in intestine, gallbladder, urinary bladder and squamous epithelia of tonsil.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012940 , CAB032687
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (lung cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA012940	CAB032687

GENE INFORMATION
Gene name	CTSE
Synonyms
Description	Cathepsin E (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	206009264 - 206023909
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196188 (version 83.38)
Entrez gene	1510
UniProt	P14091 (UniProt - Evidence at protein level)
neXtProt	NX_P14091
Antibodypedia	CTSE antibodies

PROTEIN BROWSER

CTSE-001	CTSE-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSE-001 ENSP00000350911 ENST00000358184	P14091 [Direct mapping] Cathepsin E Cathepsin E form I Cathepsin E form II Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0016540 [protein autoprocessing] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030163 [protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0070062 [extracellular exosome] Show all	396 aa 42.8 kDa	Yes	0
CTSE-002 ENSP00000353350 ENST00000360218	P14091 [Direct mapping] Cathepsin E Cathepsin E form I Cathepsin E form II Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030163 [protein catabolic process] GO:0070062 [extracellular exosome] Show all	363 aa 39.6 kDa	Yes	0