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PPIA

GENERAL INFORMATION

Gene name

 PPIA

Gene description

 Peptidylprolyl isomerase A (cyclophilin A)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA058345 , CAB004655
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA058345
CAB004655

GENE INFORMATION

Gene name

 PPIA (HGNC Symbol)

Synonyms

 CYPA

Description

 Peptidylprolyl isomerase A (cyclophilin A) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44796680 - 44824564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196262 (version 83.38)

Entrez gene

 5478

UniProt

 P62937 (UniProt - Evidence at protein level)

neXtProt

 NX_P62937

Antibodypedia

 PPIA antibodies

PROTEIN BROWSER
PPIA-001
PPIA-002
PPIA-003
PPIA-006
PPIA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPIA-001
ENSP00000419425
ENST00000468812
P62937 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
V9HWF5 [Target identity:100%; Query identity:100%]
Peptidyl-prolyl cis-trans isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002576 [platelet degranulation]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006278 [RNA-dependent DNA replication]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019061 [uncoating of virus]
GO:0019068 [virion assembly]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030260 [entry into host cell]
GO:0034389 [lipid particle organization]
GO:0042277 [peptide binding]
GO:0044822 [poly(A) RNA binding]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050900 [leukocyte migration]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 165 aa
18 kDa 		No 0
PPIA-002
ENSP00000430817
ENST00000355968
P62937 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002576 [platelet degranulation]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006278 [RNA-dependent DNA replication]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019061 [uncoating of virus]
GO:0019068 [virion assembly]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030260 [entry into host cell]
GO:0034389 [lipid particle organization]
GO:0042277 [peptide binding]
GO:0044822 [poly(A) RNA binding]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050900 [leukocyte migration]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-003
ENSP00000427976
ENST00000489459
P62937 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002576 [platelet degranulation]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006278 [RNA-dependent DNA replication]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019061 [uncoating of virus]
GO:0019068 [virion assembly]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030260 [entry into host cell]
GO:0034389 [lipid particle organization]
GO:0042277 [peptide binding]
GO:0044822 [poly(A) RNA binding]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050900 [leukocyte migration]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 105 aa
11.4 kDa 		No 0
PPIA-006
ENSP00000405975
ENST00000451562
C9J5S7 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
Show all
 121 aa
13.2 kDa 		No 0
PPIA-201
ENSP00000479961
ENST00000620047
P62937 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0002576 [platelet degranulation]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006278 [RNA-dependent DNA replication]
GO:0006457 [protein folding]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019061 [uncoating of virus]
GO:0019068 [virion assembly]
GO:0019076 [viral release from host cell]
GO:0030168 [platelet activation]
GO:0030260 [entry into host cell]
GO:0034389 [lipid particle organization]
GO:0042277 [peptide binding]
GO:0044822 [poly(A) RNA binding]
GO:0045069 [regulation of viral genome replication]
GO:0045070 [positive regulation of viral genome replication]
GO:0046790 [virion binding]
GO:0050714 [positive regulation of protein secretion]
GO:0050900 [leukocyte migration]
GO:0051082 [unfolded protein binding]
GO:0070062 [extracellular exosome]
GO:0075713 [establishment of integrated proviral latency]
Show all
 105 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.