Cell atlas - GRM7 - The Human Protein Atlas

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GRM7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	GRM7
Gene description	Glutamate receptor, metabotropic 7
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA015964
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015964	HaCaT	No staining
	HPA015964	SH-SY5Y	Cytosol
	HPA015964	U-2 OS	No staining

GENE INFORMATION
Gene name	GRM7 (HGNC Symbol)
Synonyms	GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87
Description	Glutamate receptor, metabotropic 7 (HGNC Symbol)
Entrez gene summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Chromosome	3
Cytoband	p26.1
Chromosome location (bp)	6770001 - 7741533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196277 (version 83.38)
Entrez gene	2917
UniProt	Q14831 (UniProt - Evidence at protein level)
neXtProt	NX_Q14831
Antibodypedia	GRM7 antibodies

PROTEIN BROWSER

GRM7-001	GRM7-003	GRM7-009	GRM7-012	GRM7-015	GRM7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRM7-001 ENSP00000350348 ENST00000357716	Q14831 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0001661 [conditioned taste aversion] GO:0001662 [behavioral fear response] GO:0004930 [G-protein coupled receptor activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0007613 [memory] GO:0007614 [short-term memory] GO:0008066 [glutamate receptor activity] GO:0008306 [associative learning] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0019226 [transmission of nerve impulse] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030534 [adult behavior] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0033555 [multicellular organismal response to stress] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0050877 [neurological system process] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070588 [calcium ion transmembrane transport] GO:0070905 [serine binding] Show all	915 aa 102.3 kDa	Yes	7
GRM7-003 ENSP00000373987 ENST00000389336	Q14831 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070905 [serine binding] Show all	906 aa 101.3 kDa	Yes	7
GRM7-009 ENSP00000395035 ENST00000445087	C9JMT3 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Predicted intracellular proteins Show all	GO:0005246 [calcium channel regulator activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	185 aa 21.2 kDa	No	0
GRM7-012 ENSP00000393799 ENST00000448328	C9JU97 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Predicted intracellular proteins Show all	GO:0005246 [calcium channel regulator activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	122 aa 13.5 kDa	No	0
GRM7-015 ENSP00000417536 ENST00000486284	Q14831 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001642 [group III metabotropic glutamate receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005938 [cell cortex] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007605 [sensory perception of sound] GO:0007608 [sensory perception of smell] GO:0008066 [glutamate receptor activity] GO:0010855 [adenylate cyclase inhibitor activity] GO:0014050 [negative regulation of glutamate secretion] GO:0016021 [integral component of membrane] GO:0016595 [glutamate binding] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031279 [regulation of cyclase activity] GO:0032279 [asymmetric synapse] GO:0042734 [presynaptic membrane] GO:0043198 [dendritic shaft] GO:0043235 [receptor complex] GO:0045211 [postsynaptic membrane] GO:0048786 [presynaptic active zone] GO:0051966 [regulation of synaptic transmission, glutamatergic] GO:0070905 [serine binding] Show all	922 aa 103.1 kDa	Yes	7
GRM7-201 ENSP00000384585 ENST00000402647	A0A0A0MSC3 [Direct mapping] Metabotropic glutamate receptor 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0042734 [presynaptic membrane] GO:0051966 [regulation of synaptic transmission, glutamatergic] Show all	677 aa 76.4 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.