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IARS

GENERAL INFORMATION

Gene name

 IARS

Gene description

 Isoleucyl-tRNA synthetase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA029806
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029806

GENE INFORMATION

Gene name

 IARS (HGNC Symbol)

Synonyms

 IARS1, ILRS

Description

 Isoleucyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

 Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92210207 - 92293756

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196305 (version 83.38)

Entrez gene

 3376

UniProt

 P41252 (UniProt - Evidence at protein level)

neXtProt

 NX_P41252

Antibodypedia

 IARS antibodies

PROTEIN BROWSER
IARS-001
IARS-002
IARS-006
IARS-010
IARS-201
IARS-202
IARS-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IARS-001
ENSP00000364794
ENST00000375643
P41252 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001649 [osteoblast differentiation]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006428 [isoleucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
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 1262 aa
144.5 kDa 		No 0
IARS-002
ENSP00000378922
ENST00000395554
Q5TCD1 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006428 [isoleucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
Show all
 330 aa
38.3 kDa 		No 0
IARS-006
ENSP00000387603
ENST00000430417
Q5TCC9 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005829 [cytosol]
GO:0006428 [isoleucyl-tRNA aminoacylation]
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 72 aa
8.8 kDa 		No 0
IARS-010
ENSP00000364778
ENST00000375627
Q5TCC6 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005829 [cytosol]
GO:0006428 [isoleucyl-tRNA aminoacylation]
Show all
 174 aa
19.5 kDa 		No 0
IARS-201
ENSP00000406448
ENST00000443024
A0A0A0MSX9 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006428 [isoleucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
Show all
 1242 aa
142.3 kDa 		No 0
IARS-202
ENSP00000415020
ENST00000447699
J3KR24 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic; Isoleucine-tRNA synthetase, isoform CRA_d
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006428 [isoleucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
Show all
 1152 aa
131.8 kDa 		No 0
IARS-203
ENSP00000486469
ENST00000627121
Q5TCC6 [Direct mapping]
Isoleucine--tRNA ligase, cytoplasmic
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004822 [isoleucine-tRNA ligase activity]
GO:0005829 [cytosol]
GO:0006428 [isoleucyl-tRNA aminoacylation]
Show all
 174 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.