Expression of CGB7 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CGB7

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CGB7
Gene description	Chorionic gonadotropin, beta polypeptide 7
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (BEWO, U-251 MG)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA038925 , HPA038934
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038925	HPA038934

GENE INFORMATION
Gene name	CGB7 (HGNC Symbol)
Synonyms	CG-beta-a
Description	Chorionic gonadotropin, beta polypeptide 7 (HGNC Symbol)
Entrez gene summary	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49054275 - 49058860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196337 (version 83.38)
Entrez gene	94027
UniProt	P01233 (UniProt - Evidence at protein level)
neXtProt	NX_P01233
Antibodypedia	CGB7 antibodies

PROTEIN BROWSER

CGB7-001	CGB7-002	CGB7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGB7-001 ENSP00000469076 ENST00000596965	P01233 [Direct mapping] Choriogonadotropin subunit beta A0A0F7RQF0 [Target identity:100%; Query identity:100%] Chorionic gonadotropin beta subunit 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007292 [female gamete generation] GO:0016486 [peptide hormone processing] GO:0044267 [cellular protein metabolic process] Show all	165 aa 17.8 kDa	Yes	0
CGB7-002 ENSP00000470813 ENST00000597853	P01233 [Direct mapping] Choriogonadotropin subunit beta A0A0F7RQF0 [Target identity:100%; Query identity:100%] Chorionic gonadotropin beta subunit 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007292 [female gamete generation] GO:0016486 [peptide hormone processing] GO:0044267 [cellular protein metabolic process] Show all	165 aa 17.8 kDa	Yes	0
CGB7-201 ENSP00000366493 ENST00000377280	P01233 [Direct mapping] Choriogonadotropin subunit beta A0A0F7RQF0 [Target identity:100%; Query identity:100%] Chorionic gonadotropin beta subunit 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007292 [female gamete generation] GO:0016486 [peptide hormone processing] GO:0044267 [cellular protein metabolic process] Show all	165 aa 17.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.