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ADH7

GENERAL INFORMATION

Gene name

 ADH7

Gene description

 Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Tissue enriched (esophagus)
FANTOM5:Group enriched (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in stomach. Additional expression in squamous tissue and airway epithelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA039695
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION

Gene name

 ADH7 (HGNC Symbol)

Synonyms

 ADH-4

Description

 Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 4

Cytoband

 q23

Chromosome location (bp)

 99412261 - 99435737

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196344 (version 83.38)

Entrez gene

 131

UniProt

 P40394 (UniProt - Evidence at protein level)

neXtProt

 NX_P40394

Antibodypedia

 ADH7 antibodies

PROTEIN BROWSER
ADH7-001
ADH7-002
ADH7-003
ADH7-004
ADH7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADH7-001
ENSP00000414254
ENST00000437033
A0A0C4DG85 [Direct mapping]
Alcohol dehydrogenase class 4 mu/sigma chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 374 aa
40 kDa 		No 0
ADH7-002
ENSP00000420269
ENST00000476959
P40394 [Direct mapping]
Alcohol dehydrogenase class 4 mu/sigma chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004031 [aldehyde oxidase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006068 [ethanol catabolic process]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0009617 [response to bacterium]
GO:0010430 [fatty acid omega-oxidation]
GO:0016491 [oxidoreductase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048019 [receptor antagonist activity]
GO:0055114 [oxidation-reduction process]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 394 aa
42.5 kDa 		No 0
ADH7-003
ENSP00000420613
ENST00000482593
E9PFG0 [Direct mapping]
Alcohol dehydrogenase class 4 mu/sigma chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 317 aa
33.7 kDa 		No 0
ADH7-004
ENSP00000420300
ENST00000474027
C9JP14 [Direct mapping]
Alcohol dehydrogenase class 4 mu/sigma chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 108 aa
11.6 kDa 		No 0
ADH7-201
ENSP00000209665
ENST00000209665
P40394 [Direct mapping]
Alcohol dehydrogenase class 4 mu/sigma chain
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0004022 [alcohol dehydrogenase (NAD) activity]
GO:0004024 [alcohol dehydrogenase activity, zinc-dependent]
GO:0004031 [aldehyde oxidase activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0008270 [zinc ion binding]
GO:0009617 [response to bacterium]
GO:0010430 [fatty acid omega-oxidation]
GO:0016491 [oxidoreductase activity]
GO:0019841 [retinol binding]
GO:0035276 [ethanol binding]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0048019 [receptor antagonist activity]
GO:0055114 [oxidation-reduction process]
GO:1900116 [extracellular negative regulation of signal transduction]
Show all
 386 aa
41.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.