Expression of CD55 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD55
Gene description	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Protein class	Blood group antigen proteins CD markers Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HMC-1, U-2197)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High membranous expression in most epithelial cells, trophoblasts and alveolar cells with distinct positivity in connective tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA002190 , HPA024386 , CAB010454
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002190	HPA024386	CAB010454

GENE INFORMATION
Gene name	CD55 (HGNC Symbol)
Synonyms	CR, CROM, DAF, TC
Description	CD55 molecule, decay accelerating factor for complement (Cromer blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	q32.2
Chromosome location (bp)	207321508 - 207386804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196352 (version 83.38)
Entrez gene	1604
UniProt	P08174 (UniProt - Evidence at protein level)
neXtProt	NX_P08174
Antibodypedia	CD55 antibodies

PROTEIN BROWSER

CD55-001	CD55-002	CD55-003	CD55-008	CD55-009	CD55-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD55-001 ENSP00000356031 ENST00000367064	P08174 [Direct mapping] Complement decay-accelerating factor Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0030449 [regulation of complement activation] GO:0031225 [anchored component of membrane] GO:0031664 [regulation of lipopolysaccharide-mediated signaling pathway] GO:0035743 [CD4-positive, alpha-beta T cell cytokine production] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045730 [respiratory burst] GO:0045916 [negative regulation of complement activation] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] GO:2000516 [positive regulation of CD4-positive, alpha-beta T cell activation] GO:2000563 [positive regulation of CD4-positive, alpha-beta T cell proliferation] Show all	381 aa 41.4 kDa	Yes	1
CD55-002 ENSP00000375788 ENST00000391921	B1AP15 [Direct mapping] CD55 antigen, decay accelerating factor for complement (Cromer blood group), isoform CRA_d; Complement decay-accelerating factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		317 aa 34 kDa	Yes	1
CD55-003 ENSP00000356030 ENST00000367063	B1AP13 [Direct mapping] Complement decay-accelerating factor Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004857 [enzyme inhibitor activity] GO:0007283 [spermatogenesis] GO:0016324 [apical plasma membrane] GO:0043086 [negative regulation of catalytic activity] GO:0043434 [response to peptide hormone] GO:0045916 [negative regulation of complement activation] GO:0060137 [maternal process involved in parturition] Show all	444 aa 49.3 kDa	Yes	0
CD55-008 ENSP00000340631 ENST00000343420	H3BLV0 [Direct mapping] Complement decay-accelerating factor Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		326 aa 35.7 kDa	Yes	0
CD55-009 ENSP00000316333 ENST00000314754	P08174 [Direct mapping] Complement decay-accelerating factor Show all	CD markers Blood group antigen proteins MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006958 [complement activation, classical pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0030449 [regulation of complement activation] GO:0031225 [anchored component of membrane] GO:0031664 [regulation of lipopolysaccharide-mediated signaling pathway] GO:0035743 [CD4-positive, alpha-beta T cell cytokine production] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045730 [respiratory burst] GO:0045916 [negative regulation of complement activation] GO:0046718 [viral entry into host cell] GO:0070062 [extracellular exosome] GO:2000516 [positive regulation of CD4-positive, alpha-beta T cell activation] GO:2000563 [positive regulation of CD4-positive, alpha-beta T cell proliferation] Show all	440 aa 48.7 kDa	Yes	0
CD55-201 ENSP00000356034 ENST00000367067	H7BY55 [Direct mapping] Complement decay-accelerating factor Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		550 aa 58.9 kDa	Yes	0