Expression of ASB13 in cancer - Summary - The Human Protein Atlas

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ASB13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASB13
Gene description	Ankyrin repeat and SOCS box containing 13
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA048293
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048293

GENE INFORMATION
Gene name	ASB13 (HGNC Symbol)
Synonyms	FLJ13134, MGC19879
Description	Ankyrin repeat and SOCS box containing 13 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]
Chromosome	10
Cytoband	p15.1
Chromosome location (bp)	5638867 - 5666595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196372 (version 83.38)
Entrez gene	79754
UniProt	Q8WXK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXK3
Antibodypedia	ASB13 antibodies

PROTEIN BROWSER

ASB13-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASB13-004 ENSP00000350331 ENST00000357700	Q8WXK3 [Direct mapping] Ankyrin repeat and SOCS box protein 13 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0016567 [protein ubiquitination] GO:0035556 [intracellular signal transduction] Show all	278 aa 30 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.