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INCA1

GENERAL INFORMATION

Gene name

 INCA1

Gene description

 Inhibitor of CDK, cyclin A1 interacting protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA044359
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044359

GENE INFORMATION

Gene name

 INCA1

Synonyms

Description

 Inhibitor of CDK, cyclin A1 interacting protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4988130 - 4997610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196388 (version 83.38)

Entrez gene

 388324

UniProt

 Q0VD86 (UniProt - Evidence at protein level)

neXtProt

 NX_Q0VD86

Antibodypedia

 INCA1 antibodies

PROTEIN BROWSER
INCA1-001
INCA1-002
INCA1-003
INCA1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
INCA1-001
ENSP00000460673
ENST00000576820
Q0VD86 [Direct mapping]
Protein INCA1
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Predicted intracellular proteins
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GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0030332 [cyclin binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
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 236 aa
26.8 kDa 		No 0
INCA1-002
ENSP00000461844
ENST00000575780
Q0VD86 [Direct mapping]
Protein INCA1
Show all
Predicted intracellular proteins
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0030332 [cyclin binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
Show all
 221 aa
25.2 kDa 		No 0
INCA1-003
ENSP00000458316
ENST00000574617
Q0VD86 [Direct mapping]
Protein INCA1
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Predicted intracellular proteins
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008285 [negative regulation of cell proliferation]
GO:0030332 [cyclin binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:2001235 [positive regulation of apoptotic signaling pathway]
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 236 aa
26.8 kDa 		No 0
INCA1-004
ENSP00000347129
ENST00000355025
Q0VD86 [Direct mapping]
Protein INCA1
Show all
Predicted intracellular proteins
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0030332 [cyclin binding]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
Show all
 221 aa
25.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.