Expression of PRTN3 in cancer - Summary

GENERAL INFORMATION
Gene name	PRTN3
Gene description	Proteinase 3
Protein class	Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Cell line enriched (THP-1)
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells in several tissues, most abundant in bone marrow and spleen.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA005938 , CAB017558
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005938	CAB017558

GENE INFORMATION
Gene name	PRTN3 (HGNC Symbol)
Synonyms	ACPA, AGP7, C-ANCA, MBT, P29, PR-3
Description	Proteinase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	840960 - 848175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196415 (version 83.38)
Entrez gene	5657
UniProt	P24158 (UniProt - Evidence at protein level)
neXtProt	NX_P24158
Antibodypedia	PRTN3 antibodies

PROTEIN BROWSER

PRTN3-001	PRTN3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRTN3-001 ENSP00000234347 ENST00000234347	P24158 [Direct mapping] Myeloblastin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0008236 [serine-type peptidase activity] GO:0008284 [positive regulation of cell proliferation] GO:0019899 [enzyme binding] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0050765 [negative regulation of phagocytosis] GO:0070062 [extracellular exosome] GO:0097029 [mature conventional dendritic cell differentiation] Show all	256 aa 27.8 kDa	Yes	0
PRTN3-002 ENSP00000475174 ENST00000544537	U3KPS2 [Direct mapping] Myeloblastin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	215 aa 23.6 kDa	No	0