Expression of PPP1R26 in cancer - Summary - The Human Protein Atlas

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PPP1R26

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPP1R26
Gene description	Protein phosphatase 1, regulatory subunit 26
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Sub cellular location is contradicted by limited external data.
Reliability score	Uncertain based on 1 antibody. HPA044686
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (unfavourable), pancreatic cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044686

GENE INFORMATION
Gene name	PPP1R26 (HGNC Symbol)
Synonyms	KIAA0649
Description	Protein phosphatase 1, regulatory subunit 26 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	135479079 - 135488893
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196422 (version 83.38)
Entrez gene	9858
UniProt	Q5T8A7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T8A7
Antibodypedia	PPP1R26 antibodies

PROTEIN BROWSER

PPP1R26-001	PPP1R26-002	PPP1R26-003	PPP1R26-005	PPP1R26-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPP1R26-001 ENSP00000349274 ENST00000356818	Q5T8A7 [Direct mapping] Protein phosphatase 1 regulatory subunit 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] Show all	1209 aa 127.4 kDa	No	0
PPP1R26-002 ENSP00000385826 ENST00000401470	Q5T8A7 [Direct mapping] Protein phosphatase 1 regulatory subunit 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] Show all	1209 aa 127.4 kDa	No	0
PPP1R26-003 ENSP00000474794 ENST00000605660	Q5T8A7 [Direct mapping] Protein phosphatase 1 regulatory subunit 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] Show all	1209 aa 127.4 kDa	No	0
PPP1R26-005 ENSP00000474807 ENST00000605286	Q5T8A7 [Direct mapping] Protein phosphatase 1 regulatory subunit 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] Show all	1209 aa 127.4 kDa	No	0
PPP1R26-006 ENSP00000473820 ENST00000604351	Q5T8A7 [Direct mapping] Protein phosphatase 1 regulatory subunit 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004864 [protein phosphatase inhibitor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] Show all	1209 aa 127.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.