Expression of CRYBA4 in cancer - Summary - The Human Protein Atlas

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CRYBA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRYBA4
Gene description	Crystallin, beta A4
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Group enriched (HEL, HMC-1)
HPA (normal tissue):	Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in lens.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 1 antibody. HPA071178
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA071178

GENE INFORMATION
Gene name	CRYBA4
Synonyms
Description	Crystallin, beta A4 (HGNC Symbol)
Entrez gene summary	Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	26621964 - 26630672
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196431 (version 83.38)
Entrez gene	1413
UniProt	P53673 (UniProt - Evidence at protein level)
neXtProt	NX_P53673
Antibodypedia	CRYBA4 antibodies

PROTEIN BROWSER

CRYBA4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYBA4-001 ENSP00000346805 ENST00000354760	P53673 [Direct mapping] Beta-crystallin A4 A0A097PIJ6 [Target identity:100%; Query identity:100%] Beta crystallin A4 chain; Beta crystallin A4 chain transcript PS; Crystallin, beta A4 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005212 [structural constituent of eye lens] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0007601 [visual perception] GO:0043010 [camera-type eye development] Show all	196 aa 22.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.