Cell atlas - PRPF40A - The Human Protein Atlas

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PRPF40A

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRPF40A
Gene description	PRP40 pre-mRNA processing factor 40 homolog A
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA038272 , HPA038273
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear speckles.

Main location

Nuclear speckles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038272	A-431	Nuclear speckles
	HPA038272	A-431	Cytosol
	HPA038272	U-2 OS	Nuclear speckles
	HPA038272	U-2 OS	Cytosol
	HPA038272	U-251 MG	Nuclear speckles
	HPA038272	U-251 MG	Cytosol
	HPA038273	A-431	Nuclear speckles
	HPA038273	U-2 OS	Nuclear speckles
	HPA038273	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	PRPF40A (HGNC Symbol)
Synonyms	FBP-11, FBP11, FLAF1, FLJ20585, FNBP3, HIP10, HYPA, NY-REN-6, Prp40
Description	PRP40 pre-mRNA processing factor 40 homolog A (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	152651593 - 152717997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196504 (version 83.38)
Entrez gene	55660
UniProt	O75400 (UniProt - Evidence at protein level)
neXtProt	NX_O75400
Antibodypedia	PRPF40A antibodies

PROTEIN BROWSER

PRPF40A-001	PRPF40A-004	PRPF40A-008	PRPF40A-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPF40A-001 ENSP00000386458 ENST00000410080	O75400 [Direct mapping] Pre-mRNA-processing factor 40 homolog A Show all	THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005685 [U1 snRNP] GO:0005737 [cytoplasm] GO:0007010 [cytoskeleton organization] GO:0007049 [cell cycle] GO:0008360 [regulation of cell shape] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0016477 [cell migration] GO:0016607 [nuclear speck] GO:0032465 [regulation of cytokinesis] GO:0044822 [poly(A) RNA binding] GO:0051301 [cell division] GO:0070064 [proline-rich region binding] GO:0071004 [U2-type prespliceosome] Show all	930 aa 105.9 kDa	No	0
PRPF40A-004 ENSP00000444656 ENST00000545856	F5H578 [Direct mapping] Pre-mRNA-processing factor 40 homolog A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	448 aa 48.2 kDa	No	0
PRPF40A-008 ENSP00000406924 ENST00000448428	H7C2N3 [Direct mapping] Pre-mRNA-processing factor 40 homolog A Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	163 aa 17.8 kDa	No	0
PRPF40A-016 ENSP00000441656 ENST00000493468	H0YG38 [Direct mapping] Pre-mRNA-processing factor 40 homolog A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] Show all	346 aa 36.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.