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SPTSSB

GENERAL INFORMATION

Gene name

 SPTSSB

Gene description

 Serine palmitoyltransferase, small subunit B

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (urothelial cancer)
HPA (cell line):Group enriched (MCF7, RT4)
HPA (normal tissue):Tissue enhanced (skin, stomach, urinary bladder)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SPTSSB (HGNC Symbol)

Synonyms

 ADMP, C3orf57, ssSPTb

Description

 Serine palmitoyltransferase, small subunit B (HGNC Symbol)

Entrez gene summary

 Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

Chromosome

 3

Cytoband

 q26.1

Chromosome location (bp)

 161344792 - 161372880

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196542 (version 83.38)

Entrez gene

 165679

UniProt

 Q8NFR3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFR3

Antibodypedia

 SPTSSB antibodies

PROTEIN BROWSER
SPTSSB-001
SPTSSB-003
SPTSSB-201
SPTSSB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPTSSB-001
ENSP00000352097
ENST00000359175
Q8NFR3 [Direct mapping]
Serine palmitoyltransferase small subunit B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004758 [serine C-palmitoyltransferase activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0017059 [serine C-palmitoyltransferase complex]
GO:0030148 [sphingolipid biosynthetic process]
Show all
 76 aa
9.2 kDa 		No 1
SPTSSB-003
ENSP00000420115
ENST00000497137
Q8NFR3 [Direct mapping]
Serine palmitoyltransferase small subunit B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004758 [serine C-palmitoyltransferase activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0017059 [serine C-palmitoyltransferase complex]
GO:0030148 [sphingolipid biosynthetic process]
Show all
 76 aa
9.2 kDa 		No 1
SPTSSB-201
ENSP00000483928
ENST00000617024
Q6ZWB5 [Direct mapping]
C3orf57 protein; Serine palmitoyltransferase small subunit B; cDNA FLJ41354 fis, clone BRAWH2014876
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 230 aa
24.9 kDa 		No 0
SPTSSB-202
ENSP00000480827
ENST00000620149
Q8NFR3 [Direct mapping]
Serine palmitoyltransferase small subunit B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004758 [serine C-palmitoyltransferase activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0017059 [serine C-palmitoyltransferase complex]
GO:0030148 [sphingolipid biosynthetic process]
Show all
 76 aa
9.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.