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MYO6

GENERAL INFORMATION

Gene name

 MYO6

Gene description

 Myosin VI

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035483 , CAB010762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035483
CAB010762

GENE INFORMATION

Gene name

 MYO6 (HGNC Symbol)

Synonyms

 DFNA22, DFNB37, KIAA0389

Description

 Myosin VI (HGNC Symbol)

Entrez gene summary

 This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 75749192 - 75919537

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196586 (version 83.38)

Entrez gene

 4646

UniProt

 Q9UM54 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UM54

Antibodypedia

 MYO6 antibodies

PROTEIN BROWSER
MYO6-001
MYO6-002
MYO6-003
MYO6-005
MYO6-006
MYO6-201
MYO6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO6-001
ENSP00000359002
ENST00000369985
Q9UM54 [Direct mapping]
Unconventional myosin-VI
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007268 [synaptic transmission]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0030048 [actin filament-based movement]
GO:0030139 [endocytic vesicle]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031941 [filamentous actin]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0043531 [ADP binding]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051046 [regulation of secretion]
GO:0060001 [minus-end directed microfilament motor activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 1262 aa
146 kDa 		No 0
MYO6-002
ENSP00000358994
ENST00000369977
Q9UM54 [Direct mapping]
Unconventional myosin-VI
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006605 [protein targeting]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007268 [synaptic transmission]
GO:0007416 [synapse assembly]
GO:0007626 [locomotory behavior]
GO:0008152 [metabolic process]
GO:0012506 [vesicle membrane]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016358 [dendrite development]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0030048 [actin filament-based movement]
GO:0030139 [endocytic vesicle]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030424 [axon]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031941 [filamentous actin]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0042472 [inner ear morphogenesis]
GO:0042491 [auditory receptor cell differentiation]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0043531 [ADP binding]
GO:0045177 [apical part of cell]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048839 [inner ear development]
GO:0051015 [actin filament binding]
GO:0051046 [regulation of secretion]
GO:0060001 [minus-end directed microfilament motor activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071257 [cellular response to electrical stimulus]
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 1285 aa
148.7 kDa 		No 0
MYO6-003
ENSP00000358992
ENST00000369975
A0A0A0MRM8 [Direct mapping]
Unconventional myosin-VI
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 1253 aa
145 kDa 		No 0
MYO6-005
ENSP00000399406
ENST00000430435
Q5JVM0 [Direct mapping]
Unconventional myosin-VI
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 174 aa
20.6 kDa 		No 0
MYO6-006
ENSP00000487348
ENST00000627432
A0A0D9SGC1 [Direct mapping]
Unconventional myosin-VI
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 1294 aa
149.6 kDa 		No 0
MYO6-201
ENSP00000358998
ENST00000369981
E7EW20 [Direct mapping]
Unconventional myosin-VI
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 1295 aa
149.9 kDa 		No 0
MYO6-202
ENSP00000478013
ENST00000615563
Q9UM54 [Direct mapping]
Unconventional myosin-VI
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0005938 [cell cortex]
GO:0006886 [intracellular protein transport]
GO:0006897 [endocytosis]
GO:0007268 [synaptic transmission]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016459 [myosin complex]
GO:0016461 [unconventional myosin complex]
GO:0016591 [DNA-directed RNA polymerase II, holoenzyme]
GO:0030048 [actin filament-based movement]
GO:0030139 [endocytic vesicle]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031941 [filamentous actin]
GO:0031965 [nuclear membrane]
GO:0032587 [ruffle membrane]
GO:0043531 [ADP binding]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051015 [actin filament binding]
GO:0051046 [regulation of secretion]
GO:0060001 [minus-end directed microfilament motor activity]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 1262 aa
146 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.