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The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Q969V6 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0003779 [actin binding] GO:0003785 [actin monomer binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007264 [small GTPase mediated signal transduction] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043522 [leucine zipper domain binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051145 [smooth muscle cell differentiation] GO:2001234 [negative regulation of apoptotic signaling pathway]
B0QY83 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Q969V6 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0003713 [transcription coactivator activity] GO:0003779 [actin binding] GO:0003785 [actin monomer binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0007264 [small GTPase mediated signal transduction] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0043522 [leucine zipper domain binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051145 [smooth muscle cell differentiation]
B0QY74 [Direct mapping] Phosphatase and actin regulator
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity] GO:0003785 [actin monomer binding] GO:0004864 [protein phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0043086 [negative regulation of catalytic activity]
B0QY84 [Direct mapping] Phosphatase and actin regulator
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity] GO:0003785 [actin monomer binding] GO:0004864 [protein phosphatase inhibitor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0043086 [negative regulation of catalytic activity]
E7ER32 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A087X287 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
W0Z7M9 [Direct mapping] MKL/myocardin-like protein 1; Mkl1 variant 1 Mkl1_S
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Q29R68 [Direct mapping] MKL/myocardin-like protein 1; MKL1 protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A087WU73 [Direct mapping] MKL/myocardin-like protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
