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HDAC2

GENERAL INFORMATION

Gene name

 HDAC2

Gene description

 Histone deacetylase 2

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression, accompanied by cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA011727 , CAB005054
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and breast cancer (unfavourable).
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011727
CAB005054

GENE INFORMATION

Gene name

 HDAC2 (HGNC Symbol)

Synonyms

 RPD3, YAF1

Description

 Histone deacetylase 2 (HGNC Symbol)

Entrez gene summary

 This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 113933028 - 114011308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196591 (version 83.38)

Entrez gene

 3066

UniProt

 Q92769 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92769

Antibodypedia

 HDAC2 antibodies

PROTEIN BROWSER
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HDAC2-001
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HDAC2-006
HDAC2-007
HDAC2-008
HDAC2-009
HDAC2-010
HDAC2-011
HDAC2-012
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PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC2-001
ENSP00000430432
ENST00000519065
Q92769 [Direct mapping]
Histone deacetylase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001975 [response to amphetamine]
GO:0003300 [cardiac muscle hypertrophy]
GO:0003682 [chromatin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006344 [maintenance of chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009913 [epidermal cell differentiation]
GO:0010467 [gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016358 [dendrite development]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0019213 [deacetylase activity]
GO:0019899 [enzyme binding]
GO:0031000 [response to caffeine]
GO:0031072 [heat shock protein binding]
GO:0031492 [nucleosomal DNA binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032496 [response to lipopolysaccharide]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032922 [circadian regulation of gene expression]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0033558 [protein deacetylase activity]
GO:0034605 [cellular response to heat]
GO:0035094 [response to nicotine]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042220 [response to cocaine]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042493 [response to drug]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042733 [embryonic digit morphogenesis]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045347 [negative regulation of MHC class II biosynthetic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048149 [behavioral response to ethanol]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0051059 [NF-kappaB binding]
GO:0055093 [response to hyperoxia]
GO:0060789 [hair follicle placode formation]
GO:0061000 [negative regulation of dendritic spine development]
GO:0061029 [eyelid development in camera-type eye]
GO:0061198 [fungiform papilla formation]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071300 [cellular response to retinoic acid]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1903351 [cellular response to dopamine]
GO:2000757 [negative regulation of peptidyl-lysine acetylation]
Show all
 488 aa
55.4 kDa 		No 0
HDAC2-002
ENSP00000417026
ENST00000425835
H3BM24 [Direct mapping]
Histone deacetylase 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 161 aa
18.7 kDa 		No 0
HDAC2-003
ENSP00000357621
ENST00000368632
Q92769 [Direct mapping]
Histone deacetylase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003682 [chromatin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006344 [maintenance of chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009913 [epidermal cell differentiation]
GO:0010467 [gene expression]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016358 [dendrite development]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0019213 [deacetylase activity]
GO:0019899 [enzyme binding]
GO:0031492 [nucleosomal DNA binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032922 [circadian regulation of gene expression]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0033558 [protein deacetylase activity]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045347 [negative regulation of MHC class II biosynthetic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0060789 [hair follicle placode formation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061198 [fungiform papilla formation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
Show all
 458 aa
52 kDa 		No 0
HDAC2-004
ENSP00000430008
ENST00000519108
Q92769 [Direct mapping]
Histone deacetylase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003682 [chromatin binding]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006344 [maintenance of chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009913 [epidermal cell differentiation]
GO:0010467 [gene expression]
GO:0010870 [positive regulation of receptor biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0016358 [dendrite development]
GO:0016575 [histone deacetylation]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0019213 [deacetylase activity]
GO:0019899 [enzyme binding]
GO:0031492 [nucleosomal DNA binding]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032922 [circadian regulation of gene expression]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0033558 [protein deacetylase activity]
GO:0035098 [ESC/E(Z) complex]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045347 [negative regulation of MHC class II biosynthetic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045862 [positive regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0060789 [hair follicle placode formation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061198 [fungiform papilla formation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
Show all
 458 aa
52 kDa 		No 0
HDAC2-006
ENSP00000428653
ENST00000518690
E5RGV4 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 71 aa
8.7 kDa 		No 0
HDAC2-007
ENSP00000429236
ENST00000523240
E5RJ04 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 65 aa
8.1 kDa 		No 0
HDAC2-008
ENSP00000429901
ENST00000521610
E5RH52 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 100 aa
11.8 kDa 		No 0
HDAC2-009
ENSP00000428989
ENST00000524334
E5RK19 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 52 aa
6.5 kDa 		No 0
HDAC2-010
ENSP00000428861
ENST00000520895
E5RFI6 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 60 aa
7.4 kDa 		No 0
HDAC2-011
ENSP00000427861
ENST00000523628
E5RG37 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 103 aa
12.1 kDa 		No 0
HDAC2-012
ENSP00000428599
ENST00000522371
E5RHE7 [Direct mapping]
Histone deacetylase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016575 [histone deacetylation]
Show all
 86 aa
10.4 kDa 		No 0
HDAC2-015
ENSP00000428024
ENST00000521163
E5RFP9 [Direct mapping]
Histone deacetylase 2
Show all
   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004407 [histone deacetylase activity]
GO:0016021 [integral component of membrane]
GO:0016575 [histone deacetylation]
Show all
 109 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.