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MMP1

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GENERAL INFORMATION

Gene name

 MMP1

Gene description

 Matrix metallopeptidase 1

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (HUVEC TERT2, WM-115, HBF TERT88, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA004920
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, WM-115, HBF TERT88, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004920 U-2 OS Vesicles
HPA004920 U-251 MG Vesicles

GENE INFORMATION

Gene name

 MMP1 (HGNC Symbol)

Synonyms

 CLG

Description

 Matrix metallopeptidase 1 (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

 11

Cytoband

 q22.2

Chromosome location (bp)

 102789920 - 102798160

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196611 (version 83.38)

Entrez gene

 4312

UniProt

 P03956 (UniProt - Evidence at protein level)

neXtProt

 NX_P03956

Antibodypedia

 MMP1 antibodies

PROTEIN BROWSER
MMP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP1-001
ENSP00000322788
ENST00000315274
P03956 [Direct mapping]
Interstitial collagenase 22 kDa interstitial collagenase 27 kDa interstitial collagenase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007596 [blood coagulation]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032461 [positive regulation of protein oligomerization]
GO:0044267 [cellular protein metabolic process]
GO:0050900 [leukocyte migration]
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 469 aa
54 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.