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TRPV1

GENERAL INFORMATION

Gene name

 TRPV1

Gene description

 Transient receptor potential cation channel, subfamily V, member 1

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TRPV1 (HGNC Symbol)

Synonyms

 VR1

Description

 Transient receptor potential cation channel, subfamily V, member 1 (HGNC Symbol)

Entrez gene summary

 Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 3565444 - 3609411

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196689 (version 83.38)

Entrez gene

 7442

UniProt

 Q8NER1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NER1

Antibodypedia

 TRPV1 antibodies

PROTEIN BROWSER
TRPV1-001
TRPV1-002
TRPV1-003
TRPV1-004
TRPV1-005
TRPV1-006
TRPV1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPV1-001
ENSP00000461007
ENST00000571088
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0045211 [postsynaptic membrane]
GO:0050955 [thermoception]
GO:0051219 [phosphoprotein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
Show all
 839 aa
95 kDa 		No 6
TRPV1-002
ENSP00000382661
ENST00000399759
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0045211 [postsynaptic membrane]
GO:0050955 [thermoception]
GO:0051219 [phosphoprotein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
Show all
 839 aa
95 kDa 		No 6
TRPV1-003
ENSP00000382659
ENST00000399756
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0015278 [calcium-release channel activity]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0045211 [postsynaptic membrane]
GO:0050955 [thermoception]
GO:0051219 [phosphoprotein binding]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
Show all
 839 aa
95 kDa 		No 6
TRPV1-004
ENSP00000459042
ENST00000576351
I3L1R6 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 829 aa
93.9 kDa 		No 6
TRPV1-005
ENSP00000409627
ENST00000425167
E7EQ78 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 850 aa
96.1 kDa 		No 6
TRPV1-006
ENSP00000311692
ENST00000310522
E7ESJ2 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
Show all
 779 aa
88.1 kDa 		No 6
TRPV1-009
ENSP00000459962
ENST00000572705
Q8NER1 [Direct mapping]
Transient receptor potential cation channel subfamily V member 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0001660 [fever generation]
GO:0001774 [microglial cell activation]
GO:0002024 [diet induced thermogenesis]
GO:0002790 [peptide secretion]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005216 [ion channel activity]
GO:0005231 [excitatory extracellular ligand-gated ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007635 [chemosensory behavior]
GO:0008324 [cation transmembrane transporter activity]
GO:0009268 [response to pH]
GO:0009408 [response to heat]
GO:0009897 [external side of plasma membrane]
GO:0010243 [response to organonitrogen compound]
GO:0014047 [glutamate secretion]
GO:0014832 [urinary bladder smooth muscle contraction]
GO:0015276 [ligand-gated ion channel activity]
GO:0015278 [calcium-release channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017081 [chloride channel regulator activity]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032591 [dendritic spine membrane]
GO:0034220 [ion transmembrane transport]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043434 [response to peptide hormone]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048265 [response to pain]
GO:0048266 [behavioral response to pain]
GO:0050954 [sensory perception of mechanical stimulus]
GO:0050955 [thermoception]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050968 [detection of chemical stimulus involved in sensory perception of pain]
GO:0051219 [phosphoprotein binding]
GO:0055085 [transmembrane transport]
GO:0060083 [smooth muscle contraction involved in micturition]
GO:0060454 [positive regulation of gastric acid secretion]
GO:0070588 [calcium ion transmembrane transport]
GO:0071312 [cellular response to alkaloid]
GO:0071318 [cellular response to ATP]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071502 [cellular response to temperature stimulus]
GO:0090212 [negative regulation of establishment of blood-brain barrier]
GO:0097603 [temperature-gated ion channel activity]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 839 aa
95 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.