Expression of VKORC1L1 in cancer - Summary - The Human Protein Atlas

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VKORC1L1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VKORC1L1
Gene description	Vitamin K epoxide reductase complex, subunit 1-like 1
Protein class	Enzymes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA053954
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053954

GENE INFORMATION
Gene name	VKORC1L1
Synonyms
Description	Vitamin K epoxide reductase complex, subunit 1-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q11.21
Chromosome location (bp)	65873267 - 65959563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196715 (version 83.38)
Entrez gene	154807
UniProt	Q8N0U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N0U8
Antibodypedia	VKORC1L1 antibodies

PROTEIN BROWSER

VKORC1L1-001	VKORC1L1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VKORC1L1-001 ENSP00000353998 ENST00000360768	Q8N0U8 [Direct mapping] Vitamin K epoxide reductase complex subunit 1-like protein 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0034599 [cellular response to oxidative stress] GO:0042373 [vitamin K metabolic process] GO:0047057 [vitamin-K-epoxide reductase (warfarin-sensitive) activity] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] Show all	176 aa 19.8 kDa	No	4
VKORC1L1-002 ENSP00000403077 ENST00000434382	Q8N0U8 [Direct mapping] Vitamin K epoxide reductase complex subunit 1-like protein 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0034599 [cellular response to oxidative stress] GO:0042373 [vitamin K metabolic process] GO:0047057 [vitamin-K-epoxide reductase (warfarin-sensitive) activity] GO:0048038 [quinone binding] GO:0055114 [oxidation-reduction process] Show all	177 aa 19.8 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.