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HLA-DQA1

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GENERAL INFORMATION

Gene name

 HLA-DQA1

Gene description

 Major histocompatibility complex, class II, DQ alpha 1

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HLA-DQA1 (HGNC Symbol)

Synonyms

 CELIAC1, HLA-DQA

Description

 Major histocompatibility complex, class II, DQ alpha 1 (HGNC Symbol)

Entrez gene summary

 HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.32

Chromosome location (bp)

 32628179 - 32647062

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196735 (version 83.38)

Entrez gene

 3117

UniProt

 P01909 (UniProt - Evidence at protein level)

neXtProt

 NX_P01909

Antibodypedia

 HLA-DQA1 antibodies

PROTEIN BROWSER
HLA-DQA1-001
HLA-DQA1-004
HLA-DQA1-007
HLA-DQA1-009
HLA-DQA1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HLA-DQA1-001
ENSP00000339398
ENST00000343139
P01909 [Direct mapping]
HLA class II histocompatibility antigen, DQ alpha 1 chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0010008 [endosome membrane]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031295 [T cell costimulation]
GO:0032395 [MHC class II receptor activity]
GO:0032588 [trans-Golgi network membrane]
GO:0042605 [peptide antigen binding]
GO:0042613 [MHC class II protein complex]
GO:0050852 [T cell receptor signaling pathway]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
 255 aa
28 kDa 		Yes 1
HLA-DQA1-004
ENSP00000378767
ENST00000395363
P01909 [Direct mapping]
HLA class II histocompatibility antigen, DQ alpha 1 chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0010008 [endosome membrane]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031295 [T cell costimulation]
GO:0032395 [MHC class II receptor activity]
GO:0032588 [trans-Golgi network membrane]
GO:0042605 [peptide antigen binding]
GO:0042613 [MHC class II protein complex]
GO:0050852 [T cell receptor signaling pathway]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
 255 aa
28 kDa 		Yes 1
HLA-DQA1-007
ENSP00000437302
ENST00000496318
E9PMV2 [Direct mapping]
HLA class II histocompatibility antigen, DQ alpha 1 chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II]
GO:0005515 [protein binding]
GO:0006955 [immune response]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019882 [antigen processing and presentation]
GO:0042613 [MHC class II protein complex]
Show all
 214 aa
23.7 kDa 		Yes 0
HLA-DQA1-009
ENSP00000364087
ENST00000374949
P01909 [Direct mapping]
HLA class II histocompatibility antigen, DQ alpha 1 chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0010008 [endosome membrane]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030658 [transport vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0031295 [T cell costimulation]
GO:0032395 [MHC class II receptor activity]
GO:0032588 [trans-Golgi network membrane]
GO:0042605 [peptide antigen binding]
GO:0042613 [MHC class II protein complex]
GO:0050852 [T cell receptor signaling pathway]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
Show all
 255 aa
28 kDa 		Yes 1
HLA-DQA1-010
ENSP00000405797
ENST00000422863
F6UB03 [Direct mapping]
HLA class II histocompatibility antigen, DQ alpha 1 chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.