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HIST1H2AG

GENERAL INFORMATION

Gene name

 HIST1H2AG

Gene description

 Histone cluster 1, H2ag

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SiHa, U-266/84)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 1 antibody.
HPA041189
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041189

GENE INFORMATION

Gene name

 HIST1H2AG (HGNC Symbol)

Synonyms

 H2A.1b, H2A/p, H2AFP, pH2A/f

Description

 Histone cluster 1, H2ag (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 27133042 - 27135291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196787 (version 83.38)

Entrez gene

 8969

UniProt

 P0C0S8 (UniProt - Evidence at protein level)

neXtProt

 NX_P0C0S8

Antibodypedia

 HIST1H2AG antibodies

PROTEIN BROWSER
HIST1H2AG-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H2AG-001
ENSP00000352119
ENST00000359193
P0C0S8 [Direct mapping]
Histone H2A type 1
A4FTV9 [Target identity:100%; Query identity:100%]
Histone H2A
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0019899 [enzyme binding]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 130 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.