Fields »
ABOUT
HELP
BLOG
ARHGEF12

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 ARHGEF12

Gene description

 Rho guanine nucleotide exchange factor (GEF) 12

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (approved), Cytosol (approved)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA018911
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoplasm.

Main location

 Plasma membrane (approved), Cytosol (approved)

Additional location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA018911 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA018911 U-2 OS Plasma membrane
Cytosol
HPA018911 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 ARHGEF12 (HGNC Symbol)

Synonyms

 KIAA0382, LARG

Description

 Rho guanine nucleotide exchange factor (GEF) 12 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 120336914 - 120489936

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196914 (version 83.38)

Entrez gene

 23365

UniProt

 Q9NZN5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZN5

Antibodypedia

 ARHGEF12 antibodies

PROTEIN BROWSER
ARHGEF12-001
ARHGEF12-003
ARHGEF12-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF12-001
ENSP00000380942
ENST00000397843
Q9NZN5 [Direct mapping]
Rho guanine nucleotide exchange factor 12
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1544 aa
173.2 kDa 		No 0
ARHGEF12-003
ENSP00000432984
ENST00000532993
E9PMR6 [Direct mapping]
Rho guanine nucleotide exchange factor 12
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1441 aa
161.9 kDa 		No 0
ARHGEF12-015
ENSP00000349056
ENST00000356641
Q9NZN5 [Direct mapping]
Rho guanine nucleotide exchange factor 12
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
Show all
 1525 aa
171.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.