Cell atlas - PDLIM7 - The Human Protein Atlas

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PDLIM7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Focal adhesion sites

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	PDLIM7
Gene description	PDZ and LIM domain 7 (enigma)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments & focal adhesion sites.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (validated), Focal adhesion sites (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA018794 , HPA048815
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments & focal adhesion sites.

Main location

Actin filaments (validated), Focal adhesion sites (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA018794	A-431	Actin filaments
	HPA018794	A-431	Focal adhesion sites
	HPA018794	U-2 OS	Actin filaments
	HPA018794	U-2 OS	Focal adhesion sites
	HPA018794	U-251 MG	Actin filaments
	HPA018794	U-251 MG	Focal adhesion sites
	HPA048815	U-2 OS	Nucleus
			Actin filaments
			Focal adhesion sites
	HPA048815	U-251 MG	Nucleus
			Actin filaments
			Focal adhesion sites

GENE INFORMATION
Gene name	PDLIM7 (HGNC Symbol)
Synonyms	ENIGMA
Description	PDZ and LIM domain 7 (enigma) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	177483394 - 177497606
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196923 (version 83.38)
Entrez gene	9260
UniProt	Q9NR12 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR12
Antibodypedia	PDLIM7 antibodies

PROTEIN BROWSER

PDLIM7-001	PDLIM7-003	PDLIM7-004	PDLIM7-007	PDLIM7-009	PDLIM7-010	PDLIM7-012	PDLIM7-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDLIM7-001 ENSP00000348099 ENST00000355841	Q9NR12 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0001725 [stress fiber] GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030036 [actin cytoskeleton organization] GO:0030154 [cell differentiation] GO:0045669 [positive regulation of osteoblast differentiation] Show all	457 aa 49.8 kDa	No	0
PDLIM7-003 ENSP00000352964 ENST00000359895	Q9NR12 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030154 [cell differentiation] Show all	423 aa 46.5 kDa	No	0
PDLIM7-004 ENSP00000347776 ENST00000355572	Q9NR12 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030154 [cell differentiation] Show all	222 aa 24.4 kDa	No	0
PDLIM7-007 ENSP00000377182 ENST00000393551	Q9NR12 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0015629 [actin cytoskeleton] GO:0030154 [cell differentiation] Show all	287 aa 30.4 kDa	No	0
PDLIM7-009 ENSP00000424850 ENST00000506161	D6RF83 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	173 aa 18.5 kDa	No	0
PDLIM7-010 ENSP00000421664 ENST00000506537	D6RAN1 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 9.5 kDa	No	0
PDLIM7-012 ENSP00000377177 ENST00000393546	H7BYK4 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	195 aa 20.6 kDa	No	0
PDLIM7-015 ENSP00000426213 ENST00000505074	D6RH06 [Direct mapping] PDZ and LIM domain protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	287 aa 30.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.