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PDLIM7

GENERAL INFORMATION

Gene name

 PDLIM7

Gene description

 PDZ and LIM domain 7 (enigma)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018794
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDLIM7 (HGNC Symbol)

Synonyms

 ENIGMA

Description

 PDZ and LIM domain 7 (enigma) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177483394 - 177497606

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196923 (version 83.38)

Entrez gene

 9260

UniProt

 Q9NR12 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR12

Antibodypedia

 PDLIM7 antibodies

PROTEIN BROWSER
PDLIM7-001
PDLIM7-003
PDLIM7-004
PDLIM7-007
PDLIM7-009
PDLIM7-010
PDLIM7-012
PDLIM7-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDLIM7-001
ENSP00000348099
ENST00000355841
Q9NR12 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001725 [stress fiber]
GO:0001726 [ruffle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
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 457 aa
49.8 kDa 		No 0
PDLIM7-003
ENSP00000352964
ENST00000359895
Q9NR12 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030154 [cell differentiation]
Show all
 423 aa
46.5 kDa 		No 0
PDLIM7-004
ENSP00000347776
ENST00000355572
Q9NR12 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030154 [cell differentiation]
Show all
 222 aa
24.4 kDa 		No 0
PDLIM7-007
ENSP00000377182
ENST00000393551
Q9NR12 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005925 [focal adhesion]
GO:0006898 [receptor-mediated endocytosis]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030154 [cell differentiation]
Show all
 287 aa
30.4 kDa 		No 0
PDLIM7-009
ENSP00000424850
ENST00000506161
D6RF83 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 173 aa
18.5 kDa 		No 0
PDLIM7-010
ENSP00000421664
ENST00000506537
D6RAN1 [Direct mapping]
PDZ and LIM domain protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 90 aa
9.5 kDa 		No 0
PDLIM7-012
ENSP00000377177
ENST00000393546
H7BYK4 [Direct mapping]
PDZ and LIM domain protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 195 aa
20.6 kDa 		No 0
PDLIM7-015
ENSP00000426213
ENST00000505074
D6RH06 [Direct mapping]
PDZ and LIM domain protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 287 aa
30.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.