Expression of FAM3C in cancer - Summary - The Human Protein Atlas

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FAM3C

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM3C
Gene description	Family with sequence similarity 3, member C
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA043376 , HPA050548
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043376	HPA050548

GENE INFORMATION
Gene name	FAM3C (HGNC Symbol)
Synonyms	GS3876, ILEI
Description	Family with sequence similarity 3, member C (HGNC Symbol)
Entrez gene summary	This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]
Chromosome	7
Cytoband	q31.31
Chromosome location (bp)	121348851 - 121396364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196937 (version 83.38)
Entrez gene	10447
UniProt	Q92520 (UniProt - Evidence at protein level)
neXtProt	NX_Q92520
Antibodypedia	FAM3C antibodies

PROTEIN BROWSER

FAM3C-001	FAM3C-002	FAM3C-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM3C-001 ENSP00000353025 ENST00000359943	Q92520 [Direct mapping] Protein FAM3C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005794 [Golgi apparatus] GO:0007275 [multicellular organismal development] GO:0008150 [biological_process] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0070062 [extracellular exosome] Show all	227 aa 24.7 kDa	No	0
FAM3C-002 ENSP00000408636 ENST00000412653	C9JMN4 [Direct mapping] Protein FAM3C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	151 aa 16.2 kDa	No	0
FAM3C-004 ENSP00000414940 ENST00000426156	C9JP35 [Direct mapping] Protein FAM3C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	109 aa 11.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.