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AP2A1

GENERAL INFORMATION

Gene name

 AP2A1

Gene description

 Adaptor-related protein complex 2, alpha 1 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic and occasional membranous expression

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004306
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AP2A1 (HGNC Symbol)

Synonyms

 ADTAA, CLAPA1

Description

 Adaptor-related protein complex 2, alpha 1 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49766968 - 49807113

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196961 (version 83.38)

Entrez gene

 160

UniProt

 O95782 (UniProt - Evidence at protein level)

neXtProt

 NX_O95782

Antibodypedia

 AP2A1 antibodies

PROTEIN BROWSER
AP2A1-001
AP2A1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2A1-001
ENSP00000346246
ENST00000354293
O95782 [Direct mapping]
AP-2 complex subunit alpha-1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006895 [Golgi to endosome transport]
GO:0006897 [endocytosis]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
GO:1900126 [negative regulation of hyaluronan biosynthetic process]
Show all
 955 aa
105.4 kDa 		No 0
AP2A1-008
ENSP00000351926
ENST00000359032
O95782 [Direct mapping]
AP-2 complex subunit alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006895 [Golgi to endosome transport]
GO:0006897 [endocytosis]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008022 [protein C-terminus binding]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030131 [clathrin adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032403 [protein complex binding]
GO:0032433 [filopodium tip]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043234 [protein complex]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
GO:1900126 [negative regulation of hyaluronan biosynthetic process]
Show all
 977 aa
107.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.