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Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004859 [phospholipase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0009986 [cell surface] GO:0012506 [vesicle membrane] GO:0030855 [epithelial cell differentiation] GO:0031965 [nuclear membrane] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043086 [negative regulation of catalytic activity] GO:0048306 [calcium-dependent protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051059 [NF-kappaB binding] GO:0070062 [extracellular exosome] GO:2000483 [negative regulation of interleukin-8 secretion]
