Expression of LAGE3 in cancer - Summary - The Human Protein Atlas

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LAGE3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LAGE3
Gene description	L antigen family, member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA036122 , HPA036123
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), renal cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036122	HPA036123

GENE INFORMATION
Gene name	LAGE3 (HGNC Symbol)
Synonyms	CVG5, DXS9879E, DXS9951E, ESO3, ITBA2
Description	L antigen family, member 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154477769 - 154479257
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196976 (version 83.38)
Entrez gene	8270
UniProt	Q14657 (UniProt - Evidence at protein level)
neXtProt	NX_Q14657
Antibodypedia	LAGE3 antibodies

PROTEIN BROWSER

LAGE3-001	LAGE3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAGE3-001 ENSP00000349923 ENST00000357360	Q14657 [Direct mapping] EKC/KEOPS complex subunit LAGE3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008150 [biological_process] GO:0010467 [gene expression] Show all	143 aa 14.8 kDa	No	0
LAGE3-201 ENSP00000478022 ENST00000621786	A0A0B4J2C5 [Direct mapping] EKC/KEOPS complex subunit LAGE3 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.