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ANXA6

GENERAL INFORMATION

Gene name

 ANXA6

Gene description

 Annexin A6

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA002462 , HPA009650 , CAB005077
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002462
HPA009650
CAB005077

GENE INFORMATION

Gene name

 ANXA6 (HGNC Symbol)

Synonyms

 ANX6

Description

 Annexin A6 (HGNC Symbol)

Entrez gene summary

 Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Chromosome

 5

Cytoband

 q33.1

Chromosome location (bp)

 151100712 - 151157882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197043 (version 83.38)

Entrez gene

 309

UniProt

 P08133 (UniProt - Evidence at protein level)

neXtProt

 NX_P08133

Antibodypedia

 ANXA6 antibodies

PROTEIN BROWSER
ANXA6-001
ANXA6-002
ANXA6-003
ANXA6-004
ANXA6-008
ANXA6-010
ANXA6-012
ANXA6-013
ANXA6-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA6-001
ENSP00000346550
ENST00000354546
P08133 [Direct mapping]
Annexin A6
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005925 [focal adhesion]
GO:0006816 [calcium ion transport]
GO:0006937 [regulation of muscle contraction]
GO:0008289 [lipid binding]
GO:0014704 [intercalated disc]
GO:0015276 [ligand-gated ion channel activity]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0031902 [late endosome membrane]
GO:0032403 [protein complex binding]
GO:0034220 [ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051260 [protein homooligomerization]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
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 673 aa
75.9 kDa 		No 0
ANXA6-002
ENSP00000430420
ENST00000521512
E5RK69 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 460 aa
51.8 kDa 		No 0
ANXA6-003
ENSP00000366980
ENST00000377751
E7EMC6 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 330 aa
37 kDa 		No 0
ANXA6-004
ENSP00000430517
ENST00000523714
P08133 [Direct mapping]
Annexin A6
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Transporters
   Transporter channels and pores
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005765 [lysosomal membrane]
GO:0005925 [focal adhesion]
GO:0008289 [lipid binding]
GO:0015276 [ligand-gated ion channel activity]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0031902 [late endosome membrane]
GO:0034220 [ion transmembrane transport]
GO:0042470 [melanosome]
GO:0042803 [protein homodimerization activity]
GO:0048306 [calcium-dependent protein binding]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
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 641 aa
72.4 kDa 		No 0
ANXA6-008
ENSP00000430572
ENST00000517757
E5RJF5 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 130 aa
14.7 kDa 		No 0
ANXA6-010
ENSP00000428916
ENST00000517486
E5RFF0 [Direct mapping]
Annexin A6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 156 aa
17.5 kDa 		No 0
ANXA6-012
ENSP00000431078
ENST00000523164
E5RJR0 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 110 aa
12.2 kDa 		No 0
ANXA6-013
ENSP00000430429
ENST00000521749
E5RK63 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 150 aa
16.9 kDa 		No 0
ANXA6-016
ENSP00000431086
ENST00000522664
H0YC77 [Direct mapping]
Annexin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 91 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.