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HIST1H4C

GENERAL INFORMATION

Gene name

 HIST1H4C

Gene description

 Histone cluster 1, H4c

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Not detected
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression, most abundant in proliferating cells.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 1 antibody.
HPA042201
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HIST1H4C (HGNC Symbol)

Synonyms

 dJ221C16.1, H4/g, H4FG

Description

 Histone cluster 1, H4c (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 26103876 - 26104310

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197061 (version 83.38)

Entrez gene

 8364

UniProt

 P62805 (UniProt - Evidence at protein level)

neXtProt

 NX_P62805

Antibodypedia

 HIST1H4C antibodies

PROTEIN BROWSER
HIST1H4C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H4C-001
ENSP00000367034
ENST00000377803
P62805 [Direct mapping]
Histone H4
B2R4R0 [Target identity:100%; Query identity:100%]
Histone H4
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Predicted intracellular proteins
Disease related genes
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0000228 [nuclear chromosome]
GO:0000278 [mitotic cell cycle]
GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006336 [DNA replication-independent nucleosome assembly]
GO:0006352 [DNA-templated transcription, initiation]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0031047 [gene silencing by RNA]
GO:0032776 [DNA methylation on cytosine]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0035574 [histone H4-K20 demethylation]
GO:0035575 [histone demethylase activity (H4-K20 specific)]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042393 [histone binding]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045653 [negative regulation of megakaryocyte differentiation]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0046982 [protein heterodimerization activity]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
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 103 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.